The Ackermann lab studies islet cell biology using mouse models, cell lines, and primary human tissue to investigate islet cell dysfunction in diabetes (type 1 and type 2) and congenital hyperinsulinism. Our goal is to identify novel pathways regulating beta cell insulin secretion, leading to innovative therapeutic strategies for these disorders. Current studies include a combination of in vivo mouse physiology, ex vivo human islet physiology, CRISPR-Cas9 gene editing, epigenetic modification, and single-cell functional genomics.
To investigate beta cell dysfunction in diabetes, we perform single-cell functional imaging followed by single-cell RNA-sequencing on islet cells from human donors with or without type 1 or type 2 diabetes.
For more information about the position, and to apply, please click here.